The research team “Bioanalytical Technology and Materials” from the School of Life Science and Engineering at the University recently published a paper online titled “Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis” in Advanced Materials (IF: 32.086), the top international journal for materials science and first ranking journal of the Chinese Academy of Sciences, in an effort to offer a workable clinical plan for the quick detection and treatment of septicemia.

This team led by Dr. Wu Mingyu and Prof. Feng Shun of the University, in collaboration with Dr. Gu Meijia and Prof. Chen Shi’s team of Wuhan University, aims to obtain “TBTCP-PMB engineered bacteriophage” covalently modified with the near-infrared AIE-PS (TBTCP-PMB) featuring a high fluorescence imaging function and reactive oxygen species for quick detecting and sterilizing pathogenic bacteria through a nucleophilic substitution reaction.

The research team “Bioanalytical Technology and Materials” led by Dr. Wu Mingyu and Prof. Feng Shun has been focusing on cutting-edge basic theoretical research in the field of life and health, national major demand-oriented applied research, environment, and food safety, as well as the diagnosis and treatment of serious diseases. Besides, it is dedicated to developing new materials and methods for fluorescence, electrochemistry, chromatography response/separation/enrichment, and studying their application to environmental detection, life analysis, and drug/gene delivery. With more than 20 projects at the national, provincial, and ministerial levels, it has published the research findings in many top international journals, such as PNAS, Angew, Adv. Mater., Adv. Sci., Small, Biomaterials, Sci. China. Chem., and Anal. Chem.

Link to the paper:

https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.202208578